SYRE live terminal view, Spyre Therapeutics, Inc.

SYRE · Live chart

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SYRE · Smart-money compositeas of Sep 25

0NEUTRALsmart-money positioning

-100 short0+100 long

Insiderno insider cluster in the l...

Congressno congressional trade in t...

13F fundsNEUTRAL

Short volumeFINRA short-volume is not c...

1 of 4 families contributing

SYRE · Recent signals

3 tracked funds increased SYRE this 2026Q2, institutional consensusHIGHLONGSep 16

CITADEL ADVISORS LLC added +314% to SYRE (2026Q2)HIGHLONGSep 6

CITADEL ADVISORS LLC cut 68% of SYRE (2026Q2)HIGHSHORTSep 6

CITADEL ADVISORS LLC added +76% to SYRE (2026Q2)HIGHLONGSep 6

D. E. Shaw & Co., Inc. new position in SYREMEDIUMLONGSep 6

TWO SIGMA INVESTMENTS, LP new position in SYREMEDIUMLONGSep 6

CITADEL ADVISORS LLC cut 68% of SYRE (2026Q2)HIGHSHORTSep 6

CITADEL ADVISORS LLC added +314% to SYRE (2026Q2)HIGHLONGSep 6

SYRE · Institutional holdersas of 2026Q2

MILLENNIUM MANAGEMENT LLC$17.5Mn/a

CITADEL ADVISORS LLC$9.2Mn/a

D. E. Shaw & Co., Inc.$2.3Mn/a

TWO SIGMA INVESTMENTS, LP$1.1Mn/a

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