UPB live terminal view, Upstream Bio, Inc.

UPB · Live chart

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UPB · Smart-money compositeas of Jul 30

+26LONGsmart-money positioning

-100 short0+100 long

Insiderno insider cluster in the l...

Congressno congressional trade in t...

13F fundsLONG

Short volumeFINRA short-volume is not c...

1 of 4 families contributing

UPB · Recent signals

3 tracked funds increased UPB this 2026Q1 - institutional consensusHIGHLONGJul 24

Point72 Asset Management, L.P. added +1737% to UPB (2026Q1)HIGHLONGJul 24

MILLENNIUM MANAGEMENT LLC added +81% to UPB (2026Q1)HIGHLONGJul 24

RENAISSANCE TECHNOLOGIES LLC added +279% to UPB (2026Q1)HIGHLONGJul 24

D. E. Shaw & Co., Inc. added +2929% to UPB (2026Q1)HIGHLONGJul 24

Q4-2025: Missed consensus by 11.2% - EPS $-0.785 vs $-0.7057 estimateMEDIUMSHORTJun 1

Q2-2025: Missed consensus by 19.6% - EPS $-0.74 vs $-0.6186 estimateMEDIUMSHORTJun 1

Q3-2025: Beat consensus by 20.2% - EPS $-0.63 vs $-0.7898 estimateMEDIUMLONGJun 1

UPB · Institutional holdersas of 2025Q4

MILLENNIUM MANAGEMENT LLC$14.0M+1189.5%

MILLENNIUM MANAGEMENT LLC$8.4M+81.2%

D. E. Shaw & Co., Inc.$7.4M+2928.6%

MILLENNIUM MANAGEMENT LLC$755Kn/a

D. E. Shaw & Co., Inc.$736Kn/a

RENAISSANCE TECHNOLOGIES LLC$559K+278.7%

RENAISSANCE TECHNOLOGIES LLC$445Kn/a

CITADEL ADVISORS LLC$356Kn/a

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